Product Name:Imivate Inj.

Composition:Imipenem 500 mg & Cilastatin 500 mg injection

Imipenem/ cilastatin is a broad spectrum beta-lactam antibiotic containing equal quantities of imipenem and cilastatin. It is related to the penicillin/cephalosporin family of antibiotics but is classified as belonging to the carbapenem class.

Indications& Uses:

• Lower respiratory tract infections
• Intra-abdominal infections
• Skin and skin structure infections
• Gynecologic infections
• Bone & joint infections

Pharmacokinetics:

Imipenem is a potent inhibitor of bacterial cell wall synthesis and is bactericidal against a broad spectrum of pathogens. It is resistant to degradation by bacterial β-lactamases. Cilastatin is an inhibitor of dehydropeptidase I, an enzyme found in the brush border of the renal tubules. It is given as the sodium salt with imipenem to prevent its renal metabolism and protect against nephrotoxic effects.

Absorption: IM admin: 60-75% (imipenem); 95-100% (cilastatin).

Distribution: Rapidly and widely distributed to most tissues and fluids. Protein binding: 20% (imipenem) and 40% (cilastatin).

Metabolism Imipenem: Metabolised renally by dehydropeptidase I; cilastatin: Partly metabolised

Excretion Via urine (about 70% as unchanged drug). Half-life: 2-3 hours (imipenem after IM admin).

Side Effects:

• Skin rashes
• Urticaria
• Fever
• Nausea
• Vomiting
• Diarrhoea

Contraindication:

• Pregnancy
• Lactation
• Hypersensitivity